Singh, Kawarpal, Corentin Jacquemmoz, Patrick Giraudeau, Lucio Frydman, and Jean-Nicolas Dumez. “Ultrafast 2D 1H–1H NMR Spectroscopy of DNP-Hyperpolarised Substrates for the Analysis of Mixtures.” Chemical Communications 57, no. 65 (August 12, 2021): 8035–38.
https://doi.org/10.1039/D1CC03079E.
We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.