Deo, Thomas, Qinghui Cheng, Subhadip Paul, Wei Qiang, and Alexey Potapov. “Application of DNP-Enhanced Solid-State NMR to Studies of Amyloid-β Peptide Interaction with Lipid Membranes.” Chemistry and Physics of Lipids 236 (May 2021): 105071.
https://doi.org/10.1016/j.chemphyslip.2021.105071.
The cellular membrane disruption induced by the aggregation of Aβ peptide has been proposed as a plausible cause of neuronal cell death during Alzheimer’s disease. The molecular-level details of the Aβ interaction with cellular membranes were previously probed using solid state NMR (ssNMR), however, due to the limited sensitivity of the latter, studies were limited to samples with high Aβ-to-lipid ratio.