Hi everyone,
I hope you are all having a wonderful week. I would like to invite you to the next International EPR society virtual seminar, which will occur on Wednesday, March 6th. Misa Shaw from West Virginia University School of Pharmacy will present her work on:
Development of Triarylmethyl Radical Spin Probe for in vivo Detection of Reactive Oxygen/Nitrogen Species (RONS) by Electron Paramagnetic Resonance (EPR)
Maintaining a balance, or homeostasis, of Reactive Oxygen /Nitrogen Species (RONS) with antioxidants is crucial for keeping healthy cells in our body. When a high level of RONS is observed in our body, it triggers oxidative stress associated with multiple conditions, such as cancer and cardiovascular diseases. Although it is critical to know the RONS levels in vivo, there is no reliable way to measure and image RONS in a live animal today. For instance, fluorescent probes suffer from light absorption and scattering within the tissues. Hydroxylamines or nitrones can detect ROS using EPR; nevertheless, the nitroxide radicals formed upon reaction with ROS are unstable in vivo, which does not allow enough in vivo accumulation of the nitroxide radical to be detected by EPR. To overcome the issues, we demonstrate the synthesis and characterization of a phosphine derivative of triarylmethyl radicals (TAM-PPh2) spin probe for detecting RONS using EPR. My talk will focus on the progress in the TAM-PPh2 probe development.
Webinar details:
Time: Wednesday, March 6th, 2024, 6:00 AM California/ 9:00 AM Boston/ 3:00 PM Paris/ 7:30 PM Delhi
Webinar Link: https://fsu.zoom.us/j/95942948386?pwd=WHM0T3ZyL1pEQzFaRnRnYVdBZUdJdz09
Password: IVEM
Feel free to forward this invitation to your groups and any other interested colleagues. More information can be found on our website, including information on how to join our mailing list and links to previous seminars on our youtube channel:
https://www.eprseminars.org
If you have any questions, feel free to contact anyone on the IVEM team, see the about us section of our website for contact information.
With warm regards,
Joseph
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